53 relationships, and 43 we have not established

These are relationships the ontology anticipates and the evidence does not yet support. They are listed, never drawn. Each is a specific, answerable question, and naming them is how this platform states the shape of its own ignorance.

• Acute-on-chronic liver failure → Acute decompensation — is_a, not established
• Acute liver failure → Acute-on-chronic liver failure — differentiated_from, not established
• Post-hepatectomy liver failure → ISGLS PHLF grading — classified_by, not established
• Compensated cirrhosis → Decompensated cirrhosis — progresses_to, not established
• Coagulation factor production → Coagulopathy in liver disease — causes, not established
• Detoxification and clearance → Hepatic encephalopathy — causes, not established
• Synthetic function → Ascites — causes, not established
• Bile production and excretion → Jaundice — causes, not established
• Portal hypertension → Varices — causes, not established
• Varices → Variceal bleeding — progresses_to, not established
• Portal hypertension → Ascites — causes, not established
• Portal hypertension → Splenomegaly — causes, not established
• Portal hypertension → Hepatic venous pressure gradient — measured_by, not established
• Ascites → Spontaneous bacterial peritonitis — complicates, not established
• Spontaneous bacterial peritonitis → Acute kidney injury — precipitates, not established
• Acute kidney injury → Hepatorenal syndrome — differentiated_from, not established
• Infection and sepsis in liver disease → Acute-on-chronic liver failure — precipitates, not established
• Variceal bleeding → Hepatic encephalopathy — precipitates, not established
• Acute liver failure → Cerebral oedema — complicates, not established
• Hepatic encephalopathy → Brain and nervous system — manifests_as, not established
• Hepatorenal syndrome → Kidneys — manifests_as, not established
• Hepatic encephalopathy → West Haven criteria — classified_by, not established
• Decompensated cirrhosis → Child-Pugh score — classified_by, not established
• Acute liver failure → King's College criteria — assessed_by, not established
• Hepatocellular carcinoma → BCLC staging — classified_by, not established
• Ascites → Paracentesis — treated_by, not established
• Variceal bleeding → Variceal band ligation — treated_by, not established
• Acute liver failure → Organ support in critical care — requires_referral_to, not established
• Hepatocellular carcinoma → Hepatic functional reserve — associated_with, not established
• Liver resection → Future liver remnant — assessed_by, not established
• Liver resection → Post-hepatectomy liver failure — complicates, not established
• Portal vein embolisation → Future liver remnant — targets, not established
• Compensated cirrhosis → HCC surveillance — monitored_by, not established
• Hepatic stellate cell → Hepatic fibrosis — targets, not established
• Ammonia metabolism and neurotoxicity → Hepatic encephalopathy — causes, not established
• Liver regeneration → Post-hepatectomy liver failure — associated_with, not established
• Cirrhosis-associated immune dysfunction → Infection and sepsis in liver disease — associated_with, not established
• AAV vectors → Hepatocyte — targets, not established
• siRNA → Hepatocyte-targeted conjugate delivery — delivered_by, not established
• mRNA therapeutics → Lipid nanoparticles — delivered_by, not established
• Genetic and metabolic liver disease → Genome editing — treated_by, not established
• Paracetamol overdose → Acute liver failure — causes, not established
• Acute liver failure → Liver — part_of, not established